Dr Kenneth Ritchie

Journal article

Khuniad C, Nahar L, Birkett JW, Ritchie KJ, Sarker SD. 2024. Composition of Amesiodendron chinense(Merr.) Hu Seed Oil and Assessment of Its Nrf2/ARE Induction Activity in AREc32 Cells Journal of Medicinal Natural Products, 1 Publisher Url Public Url

Nahar L, Alsheikh W, Ritchie KJ, Sarker SD. 2024. Naturally occurring eugenin: Biosynthesis, distribution, bioactivity, and therapeutic potential Phytochemistry Letters, 61 :191-197 DOI Publisher Url Public Url

Prieto JM, Fielding A, Ismail F, Nakouti I, Ehtezazi T, Rahman P, Fatokun AA, Ritchie KJ, Sarker SD. 2024. RESEARCH ACTIVITIES IN THE CENTRE FOR NATURAL PRODUCTS DISCOVERY IN 2023 Journal of Natural Products Discovery, 2 :1-6 DOI

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Evans AR, Tchinda AT, Tarkang AP, Nnanga EN, Sarker SD. 2022. Haem Polymerization Inhibitory Activity and Cytotoxicity of Six Medicinal Plants Used in Cameroon for the Management of Malaria Acta Pharmaceutica Sciencia, 60 :235-245 DOI Publisher Url Public Url

Khuniad C, Nahar L, Ritchie KJ, Sarker SD. 2022. Therapeutic potential of Leea indica (Vitaceae) Journal of Natural Products Discovery, 1 DOI Publisher Url Public Url

Popoola TD, Guetchueng ST, Ritchie KJ, Awodele O, Dempster NM, Akinloye O, Sarker SD, Fatokun AA. 2021. Potent Nrf2-inducing, antioxidant, and anti-inflammatory effects and identification of constituents validate the anti-cancer use of Uvaria chamae and Olax subscorpioidea BMC Complementary Medicine and Therapies, 21 DOI Author Url Publisher Url Public Url

Jasim HA, Nahar L, Jasim MA, Moore SA, Ritchie KJ, Sarker SD. 2021. Chalcones: Synthetic Chemistry Follows Where Nature Leads Biomolecules, 11 DOI Author Url Publisher Url Public Url

Radapong S, Chan K, Sarker SD, Ritchie KJ. 2021. Oxyresveratrol modulates gene expression of cell cycle control, apoptosis, autophagy and DNA repair in MCF-7 cells Frontiers in Pharmacology, 12 DOI Author Url Publisher Url Public Url

Radapong S, Sarker SD, Ritchie KJ. 2020. Oxyresveratrol possesses DNA damaging activity Molecules, 25 DOI Author Url Publisher Url Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Dempster NM, Nnanga EN, Sarker SD. 2020. Phenolic compounds from the leaves and stem bark of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae) Biochemical Systematics and Ecology, 91 DOI Author Url Publisher Url Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Dempster NM, Evans AR, Sarker SD. 2019. Four new neo-clerodane diterpenes from the stem bark of Croton oligandrus. Natural Product Research, DOI Author Url Publisher Url Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Dempster NM, Sarker SD. 2019. Justicialosides A and B, two new flavone glycosides from the leaves of Ruspolia hypocrateriformis (Vahl) Milne-Redh. (Acanthaceae) Phytochemistry Letters, 31 :101-103 DOI Author Url Publisher Url Public Url

Guetchueng S, Nahar L, Ritchie KJ, Ismail FMD, Evans AR, Sarker SD. 2018. Zanthoamides G-I: Three new alkamides from Zanthoxylum zanthoxyloides Phytochemistry Letters, 26 :125-129 DOI Author Url Publisher Url Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Evans AR, Sarker SD. 2018. ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex. Hutch. and Assessment of their Cytotoxicity Against Human Cancer Cell Lines Molecules, 23 DOI Author Url Publisher Url Public Url

Uddin S, Alnsour L, Segun P, Servi H, Celik S, Gokturk S, Al-Groshi A, Al-Majmaie S, Guetchueng ST, Nahar L, Dempster NM, Ismail FMD, Ritchie KJ, Sarker SD. 2017. Flavonoids from two Turkish Centaurea species and their chemotaxonomic implications Trends in Phytochemical Research (TPR), 1 :243-248 Publisher Url Public Url

Guetchueng ST, Nahar L, Ritchie KJ, Ismail, FM, Wansi JD, Evans AR, Sarker SD. 2017. Kaurane diterpenes from the fruits of Zanthoxylum leprieurii (Rutaceae) Records of Natural Products, 11 :304-309 Author Url Publisher Url Public Url

Basar N, Nahar L, Oridupa OA, Ritchie KJ, Talukdar AD, Stafford A, Kushiev H, Kan A, Sarker SD. 2016. Utilization of the ability to induce activation of the nuclear factor (erythroid-derived 2)-like factor 2 (Nrf2) to assess potential cancer chemopreventive activity of liquorice samples Phytochemical Analysis, 27 :233-238 DOI Author Url Publisher Url Public Url

Basar N, Oridupa OA, Ritchie KJ, Nahar L, Osman NMM, Sarker SD, Stafford A, Kushiev H, Kan A. 2015. Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells Phytotherapy Research, 29 :944-948 DOI Author Url Publisher Url Public Url

Henderson CJ, Ritchie KJ, McLaren A, Chakravarty P, Wolf CR. 2011. Increased skin papilloma formation in mice lacking glutathione transferase GSTP. Cancer Res, 71 :7048-7060 DOI Author Url Publisher Url

Ritchie KJ, Walsh S, Sansom OJ, Henderson CJ, Wolf CR. 2009. Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi. Proc Natl Acad Sci U S A, 106 :20859-20864 DOI Author Url Publisher Url

Ritchie KJ, Henderson CJ, Wang XJ, Vassieva O, Carrie D, Farmer PB, Gaskell M, Park K, Wolf CR. 2007. Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane. Cancer Res, 67 :9248-9257 DOI Author Url Publisher Url

Le Pla RC, Ritchie KJ, Henderson CJ, Wolf CR, Harrington CF, Farmer PB. 2007. Development of a liquid chromatography-electrospray ionization tandem mass spectrometry method for detecting oxaliplatin-DNA intrastrand cross-links in biological samples. Chem Res Toxicol, 20 :1177-1182 DOI Author Url Publisher Url

Yan M, Luo J-K, Ritchie KJ, Sakai I, Takeuchi K, Ren R, Zhang D-E. 2007. Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling. Blood, 110 :305-312 DOI Author Url Publisher Url

Rempel LA, Austin KJ, Ritchie KJ, Yan M, Shen M, Zhang D-E, Henkes LE, Hansen TR. 2007. Ubp43 gene expression is required for normal Isg15 expression and fetal development. Reprod Biol Endocrinol, 5 :13 DOI Author Url Publisher Url

Ritchie KJ, Hahn CS, Kim KI, Yan M, Rosario D, Li L, de la Torre JC, Zhang D-E. 2004. Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Nat Med, 10 :1374-1378 DOI Author Url Publisher Url

Ritchie KJ, Zhang D-E. 2004. ISG15: the immunological kin of ubiquitin. Semin Cell Dev Biol, 15 :237-246 DOI Author Url Publisher Url

Malakhova OA, Yan M, Malakhov MP, Yuan Y, Ritchie KJ, Kim KI, Peterson LF, Shuai K, Zhang D-E. 2003. Protein ISGylation modulates the JAK-STAT signaling pathway. Genes Dev, 17 :455-460 DOI Author Url Publisher Url

Ritchie KJ, Malakhov MP, Hetherington CJ, Zhou L, Little M-T, Malakhova OA, Sipe JC, Orkin SH, Zhang D-E. 2002. Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev, 16 :2207-2212 DOI Author Url Publisher Url

Malakhov MP, Malakhova OA, Kim KI, Ritchie KJ, Zhang D-E. 2002. UBP43 (USP18) specifically removes ISG15 from conjugated proteins. J Biol Chem, 277 :9976-9981 DOI Author Url Publisher Url

Campbell L, Gumbleton M, Ritchie K. 2001. Caveolae and the caveolins in human disease. Adv Drug Deliv Rev, 49 :325-335 DOI Author Url Publisher Url

Guetchueng ST, Nahar L, Ritchie KJ, Sarker SD. Evaluation of the chemopreventive effect of selected medicinal plants extracts via induction of the Nrf2 in a modified model of breast cancer cells: identification of bioactive lead compounds European Journal of Cancer Prevention, 31 :50-53 DOI Author Url Publisher Url

Khuniad C, Nahar L, Birkett J, Ritchie KJ, Sarker SD. Chemical composition and in vitro bioactivities of Amesiodendron chinense (Merr.) Hu seed oil Journal of Natural Products Discovery, 1

Chapters

Ritchie KJ, Sarker SD. 2020. Cancer chemopreventive natural products Sarker SD, Nahar L. MEDICINAL NATURAL PRODUCTS: A DISEASE-FOCUSED APPROACH 55 :273-295 ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD DOI Author Url Publisher Url

Poster

Popoola TD, Awodele O, Akinloye A, Ritchie KJ, Sarker SD, Fatokun AA. 2019. Anti-inflammatory, antioxidant and cytotoxic activities of the medicinal plants Garcinia kola, Uvaria chamae and Olax subscorpioidea validate their inclusion in indigenous anti-cancer remedies ELRIG Drug Discovery Conference 2019, 5-6 November, 2019, Liverpool, UK

Conference publication

Radapong S, Sarker SD, Ritchie KJ. 2018. Cytotoxicity of oxyresveratrol

Guetchueng ST, Nahar L, Ritchie KJ, Sarker SD. 2018. Potential cancer chemopreventive compounds Croton oligandrus Conference Abstract,

Jasim HA, Sarker SD, Moore SA, Ruparelia K, Arroo R, Ritchie KJ. 2018. Chemopreventive effect of synthetic chalcones against MDA toxicity. Abstract of the short oral presentation Conference abstract,

Jasim HA, Radapong S, Moore SA, Ruparelia K, Arroo R, Sarker SD, Ritchie KJ. 2018. Cancer chemoprevention and cancer treatment: Two opposing ends of the cancer spectrum united through their relationship with natural products Conference abstract,

Radapong S, Sarker SD, Ritchie KJ. 2018. Phytochemical analysis and pro-oxidant activity of Artocarpus lakoocha’s heartwood PSE-YSM2018 Liverpool Conference Abstract,

Jasim HA, Sarker SD, Moore SA, Ruparelia K, Arroo RRJ, Ritchie KJ. 2018. Assessment of the chemopreventive potential of a library of novel chalcones PSE-YSM2018 Liverpool Conference Abstract,

Guetchueng ST, Nahar L, Ritchie KJ, Sarker SD. 2018. Assessment of potential antimalarial activity of selected Cameroonian medicinal plants PSE-YSM2018 Liverpool Conference Abstract,

Guetchueng ST, Nahar L, Ritchie KJ, Sarker SD. 2018. Alkamides and other constituents from the fruits of Zanthoxylum zanthoxyloides PSE-YSM2018 Liverpool Conference Abstract,

Guetchueng ST, Nahar L, Ritchie KJ, Ismail FMD, Evans AR, Sarker SD. 2018. New alkaloids and other constituents from the fruits of Zanthoxylum zanthoxyloides and evaluation of their cytotoxicity International Journal of Clinical Pharmacology and drug therapy, 22nd International Congress 16 :34-34

Oridupa OA, Ritchie KJ. 2016. Induction of Nrf2 Activity by Ethyl Acetate Extract of Lagenaria Breviflora FASEB JOURNAL, Experimental Biology Meeting 30 Author Url

Osman N, Hilal M, Mohamed S, Dawood A, ritchie K, Saleem I, hutcheon G. 2015. In-vitro Stability and Degradation of PLGA and PGA-co-PDL Microparticles for Pulmonary Drug Delivery Drug Delivery to the Lungs

Osman N, Hilal M, Mohamed S, Dawood A, Ritchie K, Saleem I, hutcheon G. 2015. In vitro Stability and Degradation of PLGA and PGA-co-PDL Microparticles for Drug Delivery Controlled Release Annual Meeting Author Url

Jasim H, Radapong S, Sarker S, Ritchie K. The conundrum of phytochemicals and cancer Trends in Natural Product Research - PSE Young Scientists’ Meeting on Biochemistry, Molecular Aspects and Pharmacology of Bioactive Natural Products BUDAPEST, J

Radapong S, Sarker S, Ritchie K. New insight into the mechanisms of oxyresveratrol-induced cellular toxicity PSE-NPS 2020 summitt, "Natural Products and Healthy Living", Khulna University, Bangladesh.

Radapong S, Sarker S, Ritchie K, Ritchie K. Mechanisms of Oxyresveratrol toxicity in breast cancer cells T20 PSE Conference, Liverpool, 2020

Zavoianu A, Nahar L, Ritchie K, Sarker S. Chemopreventive property of some species from the genera Centaurea and Gardenia rends in Natural Product Research – PSE Young Scientists’ Meeting Lille 2017 Natural Products in Health, Agro-Food and Cosmetics – June 28th 2017-July 1st 2017

Jasim H, Zavoianu A, Sarker S, Moore S, Ruparelia K, Arroo R, Ritchie K. Bioactivity of synthetic chalcones in MRC-5 SV2 cells Trends in Natural Product Research - PSE Young Scientists’ Meeting on Biochemistry, Molecular Aspects and Pharmacology of Bioactive Natural Products BUDAPEST

Radpong S, Sarker S, Ritchie K. Gene expression profiles of MCF-7 cells treated with oxyresveratrol Trends in Natural Product Research - PSE Young Scientists’ Meeting on Biochemistry, Molecular Aspects and Pharmacology of Bioactive Natural Products BUDAPEST