Dr James Downing

Journal article

Pandamooz S, Jurek B, Meinung C-P, Baharvand Z, Shahem-abadi AS, Haerteis S, Miyan JA, Downing J, Dianatpour M, Borhani-Haghighi A, Salehi MS. 2022. Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments Annual Review of Pharmacology and Toxicology, 62 :25-53 DOI Author Url Publisher Url

Islam Y, Leach AG, Smith J, Pluchino S, Coxon CR, Sivakumaran M, Downing J, Fatokun AA, Teixidò M, Ehtezazi T. 2021. Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles Advanced Science, DOI Author Url Publisher Url Public Url

Islam Y, Ehtezazi P, Cashmore A, Marinsalda E, Leach AG, Coxon CR, Fatokun AA, Sexton DW, Khan I, Zouganelis GD, Downing J, Pluchino S, Sivakumaran M, Teixido M, Ehtezazi T. 2020. The Inclusion of a Matrix Metalloproteinase-9 Responsive Sequence in Self-assembled Peptide-based Brain-Targeting Nanoparticles Improves the Efficiency of Nanoparticles Crossing the Blood-Brain Barrier at Elevated MMP-9 Levels Journal of Pharmaceutical Sciences, 110 :1349-1364 DOI Author Url Publisher Url Public Url

Islam Y, Khalid A, Pluchino S, Sivakumaran M, Teixidò M, Leach AG, Fatokun AA, Downing J, Coxon CR, Ehtezazi T. 2020. Development of Brain Targeting Peptide Based MMP-9 Inhibiting Nanoparticles for the Treatment of Brain Diseases with Elevated MMP-9 Activity. Journal of Pharmaceutical Sciences, 109 :3134-3144 DOI Author Url Publisher Url Public Url

Islam Y, Leach AG, Smith J, Pluchino S, Coxon CR, Sivakumaran M, Downing J, Fatokun AA, Teixidò M, Ehtezazi T. 2020. Peptide based drug delivery systems to the brain Nano Express, DOI Publisher Url Public Url

Yaqoob N, Pritchard C, Lock EA, Downing JEG. 2009. Effects of trichloroethylene at doses inducing formic aciduria on indices of thymic selection JOURNAL OF PHARMACY AND PHARMACOLOGY, 61 :A122-A123 Author Url

Roberts M, Cespi M, Ford JL, Dyas AM, Downing J, Martini LG, Crowley PJ. 2007. Influence of ethanol on aspirin release from hypromellose matrices. Int J Pharm, 332 :31-37 DOI Author Url Publisher Url

Watt L, Allison C, Akbarian-Tefaghi N, Murphy K, Rostron C, Madden J, Downing J. 2006. Comparison of alternative methods for the assessment of gastric injury in rats treated acutely with non-steroidal anti-inflammatory drugs (NSAIDs) and their glyceryl esters JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A88-A88 Author Url

Azam M, Zhou Z, Bortell R, Downing J. 2006. Relative abundance of nitrergic cells in the thymus of non-obese diabetic (NOD) mice compared with autoimmune resistant Balb C JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A88-A89 Author Url

Omar R, Joshi H, Leposavi G, Downing J. 2006. Nitrergic cells in the thymus of Dark Agouti rats treated chronically with antagonists of alpha-1-(urapidil) and beta-(propranolol) adrenoceptors JOURNAL OF PHARMACY AND PHARMACOLOGY, 58 :A88-A88 Author Url

Shepherd AJ, Downing JEG, Miyan JA. 2005. Without nerves, immunology remains incomplete - in vivo veritas IMMUNOLOGY, 116 :145-163 DOI Author Url Publisher Url

Jones M, Sidaway L, Eadie N, Coward E, Bortell R, Downing J. 2005. Relative abundance of nitrergic cells in the thymus of diabetes resistant non-diabetic (DRnd), diabetes prone pre-diabetic (DPpd) and diabetic (DPdb) substrains of BioBreeding (BB) rat JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S40-S41 Author Url

Burns K, Karl T, von Hoersten S, Downing J. 2005. Dipeptidyl peptidase IV deficiencies are associated with low relative abundance of nitrergic cells in the thymus of sub-strains of Fischer F344 rat JOURNAL OF PHARMACY AND PHARMACOLOGY, 57 :S36-S36 Author Url

Downing JEG, Madden JC, Ingram MJ, Rostron C. 2005. Gastric and thymic assay of acute oral treatment of rats with nitric oxide esters of ibuprofen or indomethacin. Biochem Biophys Res Commun, 334 :646-653 DOI Author Url Publisher Url

Downing JE, Miyan JA. 2000. Neural immunoregulation: emerging roles for nerves in immune homeostasis and disease. Immunol Today, 21 :281-289 DOI Author Url Publisher Url

Head GM, Downing JE, Brucker C, Mentlein R, Kendall MD. 1999. Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus. Neuroimmunomodulation, 6 :31-38 DOI Author Url Publisher Url

Downing JE, Virag L, Jones IW. 1998. NADPH diaphorase-positive dendritic profiles in rat thymus are discrete from autofluorescent cells, immunoreactive for inducible nitric oxide synthase, and show strain-specific abundance differences. Immunology, 95 :148-155 DOI Author Url Publisher Url

Head GM, Mentlein R, von Patay B, Downing JE, Kendall MD. 1998. Neuropeptides exert direct effects on rat thymic epithelial cells in culture. Dev Immunol, 6 :95-104 DOI Author Url Publisher Url

Downing JE. 1997. Transient block of respiratory chain by cyanide triggers NADPH-diaphorase activity (a marker for nitric oxide synthase) in Dunning rat prostatic epithelium. Cancer Lett, 121 :91-97 DOI Author Url Publisher Url

Head GM, Mentlein R, Kranz A, Downing JE, Kendall MD. 1997. Modulation of dye-coupling and proliferation in cultured rat thymic epithelium by factors involved in thymulin secretion. J Anat, 191 ( Pt 3) :355-365 DOI Author Url Publisher Url

Downing JE, Vitanova L, Villa P. 1995. The application of in vitro isolation, cryopreservation and patch-clamp microelectrode recording methods to adult rat thymic nurse cells. J Immunol Methods, 187 :103-110 DOI Author Url Publisher Url

Grimes JA, Fraser SP, Stephens GJ, Downing JE, Laniado ME, Foster CS, Abel PD, Djamgoz MB. 1995. Differential expression of voltage-activated Na+ currents in two prostatic tumour cell lines: contribution to invasiveness in vitro. FEBS Lett, 369 :290-294 DOI Author Url Publisher Url

Downing JE. 1994. Multiple nitric oxide synthase systems in adult rat thymus revealed using NADPH diaphorase histochemistry. Immunology, 82 :659-664 Author Url

Downing JE, Djamgoź MB. 1993. Electrophysiological effects of tachykinin analogues on ganglion cell activity in cyprinid fish retina. Neuropeptides, 24 :109-116 DOI Author Url Publisher Url

Downing JE, Kaneko A. 1992. Cat retinal ganglion cells show transient responses to acetylcholine and sustained responses to L-glutamate. Neurosci Lett, 137 :114-118 DOI Author Url Publisher Url

Downing JE, Djamgoz MB. 1989. Quantitative analysis of cone photoreceptor-horizontal cell connectivity patterns in the retina of a cyprinid fish: electron microscopy of functionally identified and HRP-labelled horizontal cells. J Comp Neurol, 289 :537-553 DOI Author Url Publisher Url

Djamgoz MB, Downing JE, Wagner HJ. 1989. Amacrine cells in the retina of a cyprinid fish: functional characterization and intracellular labelling with horseradish peroxidase. Cell Tissue Res, 256 :607-622 DOI Author Url Publisher Url

Djamgoz MB, Downing JE. 1988. A horizontal cell selectively contacts blue-sensitive cones in cyprinid fish retina: intracellular staining with horseradish peroxidase. Proc R Soc Lond B Biol Sci, 235 :281-287 DOI Author Url Publisher Url

Djamgoz MB, Downing JE, Kirsch M, Prince DJ, Wagner HJ. 1988. Plasticity of cone horizontal cell functioning in cyprinid fish retina: effects of background illumination of moderate intensity. J Neurocytol, 17 :701-710 DOI Author Url Publisher Url

Poster

Islam Y, Leach A, Downing J, Fatokun AA, Sexton D, Coxon CR, Zouganelis G, Pluchino S, Sivakumran M, Teixido M, Ehtezazi T. 2019. MMP-9-responsive self-assembled nanocarriers for brain drug delivery Keele Nanoparticle Conference, Keele University, UK. 5 July, 2019.

Conference publication

Bastien M, Downing JD, Evans AR, Henney N. 2017. Identification of new alternatively spliced ghrelin variants in mouse osteoblastic cell line 7F2. 38th World Congress of the International Union of Physiological Sciences (IUPS)conference

Islam Y, Leach AG, Coxon CR, Downing J, Platt M, Pluchino S, Ehtezazi T. 2017. Smart micellar systems for brain drug delivery KTN Biopharmaceutical Formulation Group Public Url

Lilley L, Downing J, Evans AR. Treatment with components of grapefruit juice can reverse drug resistance in bladder cancer cells resistant to chemotherapeutic agent epirubicin in vitro LJMU Institute for Health Research Conference (IHR)

Bastien M, Downing J, Evans A, Henney N. A study of the role of ghrelin and ionic mechanisms in adipogenic differentiation of bone Bone Research Society Annual Meeting 2016 DOI Publisher Url

Islam Y, Leach A, Downing J, Fatokun A, Sexton D, Coxon CR, Zouganelis G, Pluchino S, Sivakumran M, Teixido M, Ehtezazi T. MMP-9-responsive self-assembled nanocarriers for brain drug delivery Keele Nanoparticle Conference

External PGR examinations performed:

University of Manchester, PhD. 2012

University of Central Lancashire, PhD. 2012